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[4] Clinical practice typically involves reviewing medication history, assessing liver function, performing a full blood count, and considering haematological or hepatological referral when levels are markedly elevated without clear cause

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Mice that overexpress Jak2VF in their erythroid lineage (VFEpoR mice) exhibit heightened necrosis in atherosclerotic plaque and erythrocytic ferroptosis, and VFEpoR increases erythrocyte lipid hydroperoxide and decreases antioxidant defense ability

Where LR3 appears in this literature it is usually as a convenient binding-protein-resistant tool for showing that an effect attributed to IGF-1 is not simply an effect on binding-protein availability, which is a legitimate and rather elegant use of it

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