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Because a large number of comparisons were performed on the relative abundance data, main effect results from these analyses also underwent a BenjaminiHochberg false discovery rate (FDR) correction for multiple comparisons, and instances where a result was significant after this correction have been duly noted

[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

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Peripheral vascular thrombosis has also occurred