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Phase 1: Weeks 14 (Adaptation) Appetite starts to shift
A meta-analysis of clinical trials suggested that the highest dose of tirzepatide (15 mg) was associated with the highest risk for nausea, vomiting, and diarrhea when compared to a placebo and other doses
Available from: Chen TK, Knicely DH, Grams ME
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This is not treatment failureit's metabolic adaptation
For me, the key is going to be access and cost, since those often become the limiting factors
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