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Research utilizing single-cell Raman microspectroscopy has demonstrated that ME/CFS patients exhibit significant aberrations in ROS clearance pathways, including elevated oxidative stress markers and reduced antioxidant enzyme activity

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2.4 Gene Expression Modulation: Genomic studies (e.g., Pickart et al., 2012) reveal GHK-Cu resets over 4,000 genes to a youthful state, upregulating repair genes and downregulating inflammatory ones, a unique epigenetic effect

Notch signaling dynamically regulates adult cell proliferation and maturity

This points to the possibility that the peptide could influence extracellular matrix maintenance, hydration, and skin barrier strength in laboratory settings