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Severe, persistent upper abdominal pain radiating to the back, worsening after eating, accompanied by nausea, vomiting, and fever are key warning signs requiring immediate medication discontinuation and emergency evaluation

Mehal said that the combination of modest weight loss results and potential side effects makes it appear unappealing as a standalone weight-loss agent

Lexaria also brought attention to the focus on adverse events with a quote[3] from Martin Holst Lange, Novo Nordisks Chief Scientific Officer: We want to win the weight loss [battle] but we also want to have a gastrointestinal adverse event profile that is attractive and competitive. On August 14 th , 2025 Lexaria announced that the last patient-last visit had been completed

It can be traced back to the idea that those in bigger bodies lack self-control and refinement, says Sabrina Strings, a professor of Black studies at the University of California, Santa Barbara, who studies portrayals of gender, race and bodies

Providers typically monitor response over time using symptoms, labs when appropriate, and safety assessments according to clinical guidance

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