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In the nervous system, Ca 2+ release into the cytosol through the mPTP activates neurotransmitter release by triggering vesicle exocytosis [186, 187]
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A.BohrV
In contrast, IL-6 trans-signaling, which has emerged as the predominant pathway by which IL-6 promotes disease pathogenesis, involves the binding of complexes of IL-6 and the soluble form of IL-6 receptor to membrane-bound gp130 (157, 158)
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