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Change history 25 July 2022 Typo in the author e-mail has been updated

et al (2024) Hyperhomocysteinemia-Induced Alterations in Protein Expression and Oxidative Stress Parameters in Rat Heart

The combination of large extracellular domains (ECD), extended orthosteric binding sites, and conformational flexibility makes class B1 GPCRs interesting but challenging targets for rational ligand discovery and particularly demanding benchmarks for computational ligand design and virtual screening methodologies (Aksu et al., 2024

Existing short-term toxicity studies, often lasting only days or weeks, do not provide sufficient evidence to support clinical translation

Several clinical scales such as CIOMS/RUCAM scale and Maria and Victorino criteria have been proposed to establish causal relationship between offending drug and liver damage

10.1038/s41419-017-0058-8 230 WangY.TangC.CaiJ.ChenG.ZhangD.ZhangZ.et al (2018b)