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There is no one size fits all answer, but here are the clinical criteria we often consider at Advanced Scripts: Semaglutide may be the right starting point if: You are new to GLP-1 therapy: It is a well-established, effective first-line treatment

Other rare side effects include increased appetite, body odor, and rash

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Combining dose tapering with intensive behavioral support (structured meal planning, accountability coaching, consistent resistance training) helps preserve 20 to 40 percent of weight loss even after treatment ends

Iron deficiency reduces exercise capacity and metabolic rate