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These include vitamin B 12 deficiency, mutations of the MTHFR gene, and epigenetic modifications that alter expression of other key enzymes involved in folate metabolism

Safety Monitoring Requirements Accelerated protocols demand more vigilant monitoring than standard approaches

They answer different quality questions: HPLC supports purity context, while MS or LC-MS/MS supports identity context

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Environmental and Other Potential Factors: While environmental exposure has been proposed as a potential factor, robust evidence linking specific chemicals, toxins, or environmental factors to MPNST remains limited

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