For research designed around four-mechanism approaches, see GLOW vs KLOW and What Is the KLOW Blend
Tryptophan products are subject non-enzyme deamination, at physiological pH, resulting in ,-unsaturated ketone, reactive intermediates 55, which can covalently bind to amino acids, usually His, Cys, or Lys residues in proteins of human lenses, or react with the Cys residue of glutathione (GSH) to form GSH-3OHKynG 54
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Notably, a reduction was observed in T3 (4.33 0.45) compared to T1 (4.95 0.47
Human glutamate cysteine ligase gene regulation through the electrophile response element
2018 Dec 31;22(4):7-19