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The most recent RDA ( Table 1 ) is based on the estimated average requirement (EAR) needed to maximize antioxidant enzyme glutathione peroxidase (GPx) activity in plasma (65)

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Existing studies are generally small in sample size and limited in follow-up duration

Both GSSG and GSSR can be catalytically reduced back to GSH by the NADPH-dependent GSH reductase and thioredoxin (Trx)/glutaredoxin (Grx) system, respectively

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The selective vulnerability in females led the authors to hypothesize a role for estrogen-linked mechanisms, although this was not tested