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There is no organ system that is not affected by this internal metabolic environment. GLP-1-based drugs are very effective at helping people reduce their calorie intake, which could directly affect insulin sensitivity and glucose metabolism, says Ard

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On top of that, none of the research Lemme points to has looked at the effects of the three main ingredients together they've only been studied individually, says Lorenz

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24-26 Despite these limitations, to our knowledge, our meta-analysis describes the largest number of patients with baseline SGLT2 inhibitor use randomized to treatment with a GLP-1 RA or placebo and, thus, the best evidence to date on the effects of the addition of GLP-1 RAs to patients treated with SGLT2 inhibitors