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reported that there were no significant differences in VLDL, LDL, TC, TG, and HDL lipid concentrations, the TC/HDL ratio, or other lipid-related parameters, such as the LDL/HDL ratio, between patients with MDD and normal control subjects

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Studies indicate that individuals with lower B12 levels are more likely to be obese[2], even after accounting for factors like diet, lifestyle and medication use

However, the lack of clinical trial data on their combination means potential interactions and safety outcomes remain inadequately studied