The differential gradient of chloride in immature neurons was shown to be primarily due to the higher concentration of NKCC1 co-transporters relative to KCC2 co-transporters in immature cells
Malhotra A et al., SURMOUNT-OSA, NEJM 2024 (NEJMoa2404881, PMID 38912654) : tirzepatide and obstructive sleep apnea, AHI -25,3 to 52 weeks
37 It's often best to change just one variable at a time
That being said, liraglutide was used successfully in the small trial at Penn for opioid cravings, discussed above, and as a generic it may be a more affordable option in some situations
The three paths forward after reaching your goal Once you reach your target weight or a satisfactory point, you face three options
The most common downside is an increased risk of urinary tract and genital yeast infections due to the extra glucose passing through your urine