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These residues are often involved in substrate binding, e.g

When both arrive at the same time, the pituitary responds with a larger, more coordinated GH pulse than either produces alone without them competing or cancelling each other out

Dutasteride is particularly relevant for people who have tried finasteride with limited results, since the more complete DHT suppression it provides often yields better outcomes for those who don't fully respond to Type 2 inhibition alone

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