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[8] Tchang, B.G., et al

In such severe cases, cerebral oedema becomes clinically apparent 12 hours to 4 days after the overdose [18, 20, 50, 87], although CNS depression may be delayed if a slow-release preparation has been ingested [12, 50]

Extended Data Extended Data Fig

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The expanded Enterobacteriaceae release LPS, activating the TLR4/MyD88 axis to upregulate epithelial NOX1 expression, thereby driving secondary ROS bursts that amplify epithelial barrier disruption and inflammatory cascades [404]