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doi: 10.1210/clinem/dgz275 9 ForheadAJFowdenAL

Cabou C, Vachoux C, Campistron G, Drucker DJ, Burcelin R: Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-delta

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Normal fatigue on GLP-1 medication: Feeling moderately tired after training but recovering within 24 to 48 hours Slight strength reduction (5 to 10 percent) during the first month that stabilizes Mild muscle soreness that resolves within 48 hours Energy that improves after the first 4 to 6 weeks as your body adapts Warning signs that require adjustment: Strength declining consistently over multiple weeks Muscle soreness persisting beyond 72 hours after a session Feeling exhausted before training even begins Frequent illness, joint pain, or mood changes Sleep quality worsening despite good sleep hygiene Loss of motivation that extends beyond the gym If youre experiencing three or more warning signs, reduce training volume by another 20 percent, add a rest day, audit your calorie and protein intake, and consult with both your prescribing physician and a qualified trainer

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