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The parental INS-1 (832/13) cell line was kindly provided by Chris Newgard 40
This imbalance in macrophage polarization underscores the inflammatory mechanisms driving hepatic metabolic dysfunction and highlights a potential therapeutic target for mitigating MASLD-associated insulin resistance (209)
GLP-1 Reduces appetite, slows gastric emptying GIP Enhances insulin, improves fat metabolism Glucagon Increases energy expenditure, burns fat Based on Phase 2 clinical trial data (published in NEJM, 2023), retatrutide's side effects are primarily gastrointestinal, similar to other GLP-1 agonists but with some differences due to the glucagon component
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