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The early role of UPR is to reduce translation to lessen the need for new protein folding, degrade unfolded proteins to minimize damage, and increase the expression of chaperone proteins to assist protein folding

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Gastroparesis remains the most widely studied and clinically challenging manifestation, and treatment with currently available modalities can often be suboptimal

Vitamin C, E, B1, B2, B6, B9, B12 and minerals selenium, zinc, magnesium are cofactors for glutathione production

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Meanwhile, among the current market leaders, Novo screens as the most attractive from a valuation and ESG risk perspective