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Freezing causes ice crystals to form within the solution, which ruptures the molecular bonds of the GLP-1 agonist

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Unlike the above models, in which activation of sAC was studied after injury, we demonstrate that GLP-1(2836) acts as a preconditioning agent by activating sAC through increased production of ATP, leading to downstream cAMP/PKA activation

315 Subsequently, rats were treated with liraglutide through subcutaneous injection to observe its therapeutic effect on OA

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Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, et al