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This delayed gastric emptying effect may attenuate somewhat with continued use but remains clinically significant

Rapid dose escalation can overwhelm the nervous system in susceptible individuals, making slower titration schedules advantageous

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Pharmacists may wish to lengthen the duration between starting dose and dose increase, and should routinely check the summary of product characteristics (SPC) for individual drugs for more information

Treatment duration varies based on individual response, tolerability, and treatment goals, though many patients require long-term or indefinite therapy to maintain benefits

Cellular iron homeostasis also depends on iron regulatory proteins and iron-responsive elements (36)