As shown in Table 1 [1,8,12-19] , because of the critical role of this pathway in energy regulation, functional abnormalities caused by mutations in any of its critical genes (e.g., LEP , LEPR , POMC , PCSK1 , MC4R ) can lead to severe early-onset obesity and extreme hyperphagia and are often accompanied by endocrine abnormalities due to deficiencies in related hormones, such as hypogonadism and hypothyroidism [12,20]
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Selenoprotein P expression is controlled through interaction of the coactivator PGC-1 with FoxO1a and hepatocyte nuclear factor 4 transcription factors
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Additionally, the histology results found that 10 minutes post-injury a large hemorrhagic zone was observed over the white columns in the test subjects, but no change in the gray matter