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A Summary Davins viewpoint on supplements for melasma Dr Davin Lim | Dermatologist The Melasma Clinic, Sydney | Australia Two ways to view supplements for melasma, firstly the natural & holistic way, secondly as a last-ditch effort to treat resistant melasma

Restoring mitochondrial biogenesis with metformin attenuates -GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis

Tirzepatide decreases oral contraceptive exposure by about 20%, which increases the risk of pregnancy

L-carnitine may offer a small supplementary effect

Adverse effects include: Other possible side effects include redness or swelling, burning or stinging sensation, and itchy or flaky skin

Hydration Drink plenty of water to support detoxification