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Side effects can be mitigated with an increase in nutritional supplement and protein intake
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Predominantly, the ECM consists of proteoglycans, glycoproteins, various matrix proteins (such as SPARC/osteonectin, OPN/SPP-1, and THBS/TSP, which are abundant in cysteine residues), and structural proteins (including fibrillin, collagen, and laminin) [54]
For most patients, gastrointestinal side effects are mild to moderate and tend to improve as the body adjusts to the medication
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