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Clinical Trial Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

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Furthermore, chronic administration of the synthetic FXR agonist GW4064 exacerbates weight gain, dyslipidemia, and glucose intolerance in obese, insulin-resistant mice [90]

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That means 84% of what you're taking is essentially wasted