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These medications potently and selectively inhibit the enzymatic activity of DPP-4, enhancing the effectiveness of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), which are the primary incretins (endogenous glucoregulatory peptides, [39,40,41])

AR-V7 enhanced glycolytic flux more effectively than AR-FL with enhanced conversion of glutamine to citrate via reductive carboxylation (114)

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For patients who want a stronger appetite effect, we also discuss tirzepatide (Mounjaro) as an alternative

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The published clinical evidence behind GLP-1 medications as a class is substantial