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Local GI Effects: For applications related to gut lining, oral administration may provide direct topical contact with intestinal tissues in theory

(The same questions have been asked regarding thyroid medicine

Food and Drug Administration) Also worth noting: in that same FDA update, CJC-1295 and Ipamorelin acetate were described as removed from Category 2 due to nominations being withdrawn while FDA indicated it planned to consult its advisory committee about potential inclusion of related substances