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Common, expected injection site reactions include: Redness or erythema at the injection site Mild swelling or oedema Bruising or haematoma formation Itching or mild discomfort Small, firm nodules beneath the skin (particularly if sites are not rotated) These reactions are typically self-limiting

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In 2021, a new GLP-1 receptor agonist, semaglutide 2.4mg, was approved by the US Food and Drug Administration (FDA) for the management of chronic obesity

The mechanism of action involves dual agonism at both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors