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Status of clinical trials involving anti-IGFs and IGF-1R mAbs The preclinical findings that support IGF-1 and its receptor IGF-1R as potential therapeutic targets led to the initiation of many clinical trials in the last decade (Table 1)

The possibility of minimizing iron intake or removing iron may prove beneficial for the treatment of liver injury and it is clearly an area that deserves further research ( For investigating the pathogenesis and treatment of APAP-induced hepatotoxicity, the role of iron was evaluated as was whether PA played a role in the treatment of APAP-induced hepatotoxicity in light of its importance as an iron chelator and its ability to block the generation of iron-driven hydroxyl radicals as well as the suppression of lipid peroxidation (Omoruyi et al., 2013)

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doi: 10.3389/fphar.2017.00220 183 MillerM

Laboratory findings suggesting interactions with DNA sequences, chromatin or gene expression remain mechanistic hypotheses

In fact, the blockade of dopamine receptors by metoclopramide caused the increase in LH plasma levels in women with hypothalamic amenorrhea but not in eumenorrheic women [22], thus supporting the evidence of an impaired dopaminergic activity in stress-induced amenorrhea