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known trial-reported adverse effects include gastrointestinal symptoms, injection site reactions, increased heart rate, and hypoglycaemia risk

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When Histamine Symptoms Extend Beyond Food A low-histamine diet may reduce meal-triggered symptoms, but it cannot by itself determine whether the patient has undermethylation, copper overload, pyroluria, mast-cell activation or another biochemical pattern

doi:10.1016/b978-0-323-47720-8.00016-x