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3 Nanotechnology-enabled strategies to overcome immunosuppressive barriers 3.1 Reprogramming the tumor-associated macrophage compartment Given the central role of M2-polarized TAMs in maintaining immunosuppression within the osteosarcoma TME, strategies to reprogram these cells toward a pro-inflammatory M1 phenotype have attracted considerable attention

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5 Human trials corroborate these findings, as individuals with metabolic syndrome consuming 250500 mg of amla fruit extract twice daily for 12 weeks exhibited reduced lipid peroxidation and increased GSH levels

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