Lancet Diabetes Endocrinol 2022;10:393-406.ArticlePubMed 134
The representative synthetic compound targeting Nrf2 is melatonin, an amine hormone secreted by the brains pineal gland [203]
10.1016/j.anai.2020.08.016 Ann Allergy Asthma Immunol
Its biological meaning depends heavily on context, including the tissue being studied, the local oxidative environment, the NOS isoform involved, and the timing of measurement after experimental injury or stimulation
As part of its wound healing effect, GHK-Cu has been shown to contribute to the initial upregulation of growth factors and inflammatory mediators during nerve regeneration [8]
The researchers notably found that epithalamin not only produces direct antioxidant effects, but also stimulates the expression of antioxidant enzymes like superoxide dismutase and ceruloplasmin [10]