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FDA crackdown on compounding pharmacies (2023-2024) What happened: FDA increased scrutiny of compounded semaglutide Concerns about shortages vs compounding exemptions Some compounding pharmacies received warning letters Impact: Harder to get compounded versions of FDA-approved drugs Some clinics stopped offering certain peptides Shifted more toward truly non-approved peptides Takeaway: Regulatory environment tightening around compounded versions of FDA-approved drugs

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Overview of GLP-1 peptide drugs: Liraglutide: A daily injectable GLP-1 analog engineered to resist DPP-4 degradation

Tirzepatide mostly causes gastrointestinal side effects, including nausea, vomiting, and bloating

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