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421,422 Long-term management of HTG is essential to prevent the recurrence of HTG-AP

It may not improve performance and costs more

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Key advantages: Oral administration (no injection burden) Scalable manufacturing Potential for combination therapies Broader patient adherence However, these molecules also reintroduce important questions: Will small-molecule receptor activation alter tissue selectivity

Moreover, clinical studies analyzing reliable markers for pathophysiological active iron overload and prospective studies exploring function of iron-homeostasis targeting drugs are essential