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GLP-1R was initially discovered on pancreatic -cells [5, 6], highlighting GLP-1s crucial role in regulating blood sugar homeostasis
These agents modulate neurotransmission, reduce neuroinflammation and oxidative stress, enhance mitochondrial and neurotrophic function, and improve insulin sensitivity and hypothalamic-pituitary-adrenal (HPA) axis regulation
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Semaglutide and cardiovascular outcomes in patients with type 2 diabetes
Activation of glucagon-like peptide-1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/akt pathway
The standard clinical protocol involves gradual dose escalation designed to minimize gastrointestinal side effects while building toward therapeutic levels
