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These drugs were promising early on, but many were abandoned for either failing to show clear benefits or for allegedly causing severe side effects

Clin Dysmorphol

Reconstitute with bacteriostatic water, inject diluent slowly down the vial wall without shaking, and store at 28C once reconstituted

ARA-290 improved neuropathic symptoms and metabolic markers in type 2 diabetes patients

In studies comparing the effect of oral and parenteral cobalamin, large doses (2 to 3 mg) of daily oral B12 appear equally effective to daily parental cobalamin 1 mg in rapidly restoring cobalamin stores and treating the signs of deficiency (215

However, its risk-benefit profile is still unclear at this stage, which is why it is not approved by the FDA