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As the Urano group pointed out, using QuicGSH to monitor the global GSH dynamics requires a bold assumption that the mitochondrial and global GSH are at similar levels
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This is called dose titration and its exact application varies from drug to drug
Moore MW, Gasparini R
While no effect of water volume with dosing on SNAC pharmacokinetics was observed, interestingly, SNAC exposure increased when shortening the post-dose fasting period from 120 to 30 min in the dosing conditions trial (Supplementary Fig
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