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Pharmacokinetic considerations help explain this timeline

Lamour, V., Kaplan, M

Several studies/trials have reported a beneficial effect of weight loss on additional cardiovascular disease risk factors, including blood pressure, diabetes, and plasma lipid levels as well as a reduction in cardiovascular events

The peptide appears to act on fat metabolism without influencing appetite

This process continues until all the by-products are excreted or recycled into something else

The exact cause of nausea from semaglutide isnt fully understood, but its thought to be related to how the medication affects the digestive system and the central nervous system