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Comparison: MOTS-c + 5-Amino-1MQ Synergy vs Monotherapy Key Takeaways MOTS-c activates AMPK to increase mitochondrial function and fat oxidation, while 5-Amino-1MQ inhibits NNMT to preserve NAD+ poolstargeting complementary metabolic pathways

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Microglia can be artificially activated by LPS, which induces a switch from a protective to pro-inflammatory state with the production of IL-12, TNF, NO, superoxide anions, and peroxynitrite (H 2 O 2 ), causing motor neuron degeneration and exacerbation of disease progression in fALS mice [124126]