Plasma homocysteine and cardiovascular disease mortality
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Of them, sodium ferulate (SF) features low toxicity, stability, ease of synthesis, and water solubility and has been authorized by the State Drug Administration of China as an adjuvant drug for treating ischemic cardiovascular diseases [166, 167]
Some DNA methylation in the promoter regions of specific genes related to lipid metabolism (PPARG, PPARA), 212 low-density lipoprotein receptor-related protein 1 (LRP1), 213 lipoprotein lipase (LPL), 214 SREBF1/2, 215 and inflammation (stearoyl-CoA desaturase 1 (SCD1), chemokine C-C motif chemokine ligand 2 (CCL2), TNF-, and TGF-1) 216,217 are associated with adipose tissue dysfunction and could lead to metabolic disorders
However oral GSH supplementation has poor bioavailability largely because it is so rapidly oxidised to GSSG as it disarms free radicals
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