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Association between GLP-1 receptor agonists and incidence of lung cancer in treatment-nave type 2 diabetes

Metformin has been the backbone of Type 2 diabetes treatment for decades, and it remains the recommended starting point in most guidelines

Additionally, GLP-1RAs facilitate the maintenance of endothelial barrier integrity, thus playing a crucial role in preventing vascular leakage.452 Endothelial cells exhibit enhanced NO production and concurrent suppression of endothelin formation, resulting in vascular smooth muscle relaxation and vasodilation mediated by the endothelium (e.g., GLP-1, exenatide, and liraglutide).453 Indeed, GLP-1RAs, including exenatide, liraglutide, and semaglutide, have been linked to the diminished expression of matrix metalloproteinases (MMPs).454,455,456 MMPs are a class of enzymes that play a crucial role in the breakdown of extracellular matrix components

GIPs effects on appetite and brain signaling are less clear than GLP-1s

As one of the editors, alongside an outstanding team including Stacy Brethauer, Matthew Hutter, Teresa Lamasters, JOHN MORTON, and Ann Rogers, I am proud to see this comprehensive resource now available to the bariatric and metabolic surgery community

Our selection of FDA-approved medications, including Wegovy, Zepbound, and Foundayo, offers McHenry residents effective solutions for lasting weight management