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N Engl J Med, 375:1834-1844

In addition, Nrf2 can also regulate the expression of downstream enzymes such as GST and GR, further improving the cell's antioxidant defense network and enabling cells to more effectively respond to damage caused by oxidative stress

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The beneficial effect of GLP-1RAs on the state of the neurovascular unit has been shown, which can significantly contribute to the neuroprotective effects of these drugs in NDD [48]

A patient may achieve their glycemic target while kidney damage continues to progress silently

This pattern aligns with decades of diabetes research demonstrating that while rapid glycemic improvement carries short-term risks for retinopathy progression, sustained long-term glucose control reduces the incidence and severity of diabetic eye disease