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GLP-1RA or dual GIP/GLP-1RA added to basal insulin compared to basal insulin titrated with a rigorous intention-to-treat approach is moderately effective in preventing further increase in daily basal insulin dose from achieving treat-to-target glycemic goals ( daily insulin dose, SMD -0.49, 95% CI -0.71
Mandru R, Zhou CY, Pauley R, Burkes RM
showed an association between the expression of CPT1C and ZFP57, a zinc finger protein involved in gene imprinting 50
It is primarily metabolized by the liver, broken down into metabolites, some of which can be toxic in large amounts
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