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Bioengineering 9 , (2022)

During clinical trials, melanotan II consistently produced spontaneous erections and increased sexual desire in male subjects a side effect significant enough to warrant development of a dedicated compound

Nonetheless, gastrointestinal adverse symptoms (e.g., nausea, vomiting) persist often, and long-term safety data are still being examined

Robin P, Boulven I, Ble-Feysot C (2004) Contribution of PKC-dependent and -independent processes in temporal ERK regulation by ET-1, PDGF, and EGF in rat myometrial cells

Sex and gender were considered in the study design without restrictions on enrollment

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