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Richard Heyer, a dermatologist at the University of Michigan, stated in a 2023 interview with Dermatology Times : "Copper peptides have compelling preclinical biology, but we need well-powered RCTs before we can recommend them with the same confidence as retinoids or established growth factors." This perspective reflects the broader clinical sentiment

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There are a few reasons why it might be a better idea to avoid OTC supplements

Cardiovascular health: Selenium-dependent glutathione enzymes protect blood vessels from oxidative damage, while vitamin C supports collagen in arteries

The next stage of skincare introduced increasingly concentrated single-ingredient treatments

Over several weeks, steadier support as your baseline levels rebuild, especially if you were low