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Method of Literature Search PubMed and the Cochrane Library were searched in April 2021 (Figure 1)

It is important to note that weight loss is more than just a number

Interestingly, these neuroprotective features have also been shown in humans, where post-menopausal women taking HRT, had fewer and smaller damaged areas after an ischemic event comparing to controls (non-HRT) (Gibson et al., 2006)

On the other hand, common neurological diseases, e.g., Alzheimers disease have pronounced both marked sex-dependency (Ferretti et al., 2018) and involvement in the BBB decline (Zenaro et al., 2017)

Research has explored its potential effects on pigmentation pathways, immune modulation, and receptor binding characteristics in controlled laboratory models

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