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Sources FDA: U.S

Your body needs time to adjust to each: GLP-1 receptor: Slows gastric emptying, reduces appetite GIP receptor: Enhances insulin signaling, affects fat metabolism Glucagon receptor: Increases energy expenditure, promotes fat oxidation Jumping to high doses overwhelms these systems, causing: Severe nausea and vomiting Treatment discontinuation Longer overall time to reach therapeutic doses The data: In the Phase 2 NEJM study, participants who started at 4 mg instead of 2 mg had significantly higher rates of gastrointestinal side effects

I plan to order again for the following month and I will do another review

- Experienced HRT Patient Reviewer Aug 23, 2025 5 min read Updated: Oct 5, 2025 I've been on Hormone Replacement since December 2019

Like obstructions of the small intestine, an untreated blockage in the bowel could lead to tissue death, peritonitis, or sepsis