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This involves the activation of CHOP and the ER-resident caspase-12, further propagating the apoptotic signal
GLP-1R action on brown adipose tissue (BAT) thermogenesis In addition to causing changes in feeding, central GLP-1R activation may regulate body weight by increasing brown adipose tissue (BAT) thermogenesis (reviewed in Lockie et al., 2013)
The median follow-up duration was 1 year (IQR: 0.52 years), with key findings including a median weight loss of 11.7 kg and a median BMI at the most recent follow-up of 31.2 kg/m 2 , reflecting a median reduction of 3.7 kg/m 2
So how did we get from GLP-1 for diabetes to GLP-1 for weight loss
Competing interests None declared
In another study performed to examine the potential cardioprotective effects in elderly hearts, a model of aging rats was used in which the effects were tested in aged rats
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