Genetics, starting weight, metabolic rate, activity level, diet quality, sleep, stress, and dozens of other factors all influence your response
The 28.7% figure for retatrutide comes from TRIUMPH-4, a Phase 3 trial of 445 adults living with obesity and knee osteoarthritis, reported by Lilly in a December 2025 press release
---- Lubberding AF, Veedfald S, Achter JS, Nissen SD, Soattin L, Sorrentino A, Vega ET, Linz B, Eggertsen CHE, Mulvey J, Torng S, Larsen SA, Nissen A, Petersen LG, Bilir SE, Bentzen BH, Rosenkilde MM, Hartmann B, Liller TNB, Qazi S, Mller CH, Tfelt-Hansen J, Sattler SM, Jespersen T, Holst JJ, Lundby A
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Antioxidants & redox signaling 14, 23472360 (2011)
Skipping a single weekly injection does not derail your weight loss progress or reverse the medication's effectstirzepatide has a long half-life, meaning it remains active in your system for several days after injection