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Vitamin B6 (Pyridoxine) acts as a necessary cofactor in the folate cycle and combines with serine hydroxymethyl transferase to effect the conversion of tetrahydrofolate(THF) to 5,10 methylene THF (14)
Specifically, the enhanced anxiolytic effects seen with DSIP-CBBBP treatment compared to DSIP alone likely arise from the synergistic role of CBBBP and DSIP